European Journal of Inorganic Chemistry, 6.
This article has been cited by other articles in PMC. Important design modifications include thin strut stent backbones, less inflammatory and more biocompatible polymers, and lower drug dosing.
In animal models, this stent demonstrated minimal vessel inflammation, a biologically active endothelium with strut coverage similar to a bare metal stent, and inhibition of intimal hyperplasia comparable to that seen with sirolimus-eluting stents.
The SPIRIT family of clinical trials demonstrated low rates of late loss, and clinical restenosis, as well as low rates of very late stent thrombosis. These excellent clinical outcomes addressed limitations of the 1st generation DES, and substantiated widespread clinical use of the EES platform.
While reductions in target vessel failure TVF were clearly achievable in animal models, translation of reductions in restenosis with a successful stent platform in patients would take time. Eventually, through the engineering of better polymers, platforms, and pharmacology, the 1st generation DESs ie, sirolimus, paclitaxel demonstrated sustained reductions in rates of restenosis compared to bare metal stents BMS.
The benefits of the 1st generation DESs were demonstrated out to five years, with durable results for significant reduction in target vessel revascularization TVR Their thick strut platforms Fig.
Additionally, clinical studies showed bare metal thinner strut platforms achieving less angiographic restenosis when compared to thick strut DES platforms.
The goal of better endothelial coverage with less inflammation and enhanced delivery fueled the development of 2nd generation DESs.
The following is an in-depth review of the everolimus-eluting stent platform EESthe most widely used and studied of these 2nd generation DESs.article paper manuscript chapter commentary essay ^ (70) care ^ (96) visit appointment check-up timepoint ^ () visits appointments check-ups visitation permanente attenders attendances generation millennium messengers ^ (43) field ^ ().
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The Second Round of the European Social Survey Series in Hungary. Project Report. OTKA. Anton, Attila.
Alberta Wetlands: A Law and Policy Guide, Second Edition. (Canadian Institute of Resources Law and North American Waterfowl Plan Partnership), pp. A Conservation Easement Guide for Alberta, , (Environmental Law Centre). Machan has performed multiple first-in-man procedures including the first drug eluting stent implantation in , and the first drug eluting vascular stent in Colombo's Tips & Tricks for Drug Eluting Stents, Antonio Colombo, Goran Stankovic The Book of Common Prayer - And Administration of the Sacraments and Other Rites and Ceremonies of the Church, Church Publishing.
"Employment generation in rural Africa: mid-term results from an experimental evaluation of the Youth Opportunities Program in Northern Uganda," Social Protection and Labor Policy and Technical Notes , The World Bank.